|
KMID : 0382419990250040124
|
|
Korean Journal of Environmental Health Society
1999 Volume.25 No. 4 p.124 ~ p.129
|
|
|
The Effect of Chitosan on the Development of Aberrant Crypt Foci Induced by Azoxymethane in Rat Colon
|
|
|
|
|
Abstract
|
|
|
|
An investigation was conducted to assess the chemopreventive effects of chitosan in a rat preneoplastic colorectal carcinogenesis induced by azoxymethane (AOM). Thirty, 5-week-old, male F344 rats were divided into three groups. CRF-1 diet containing 2% chitosan and control diet were fed to the rats of group 1 and 2, respectively, for 12 weeks. AOM (15 mg/kg body weight, subcutaneously) were given to the rats three times for 2 weeks from week 2. The treatment regimen to the rats of group 3 were same to the group 1 except that saline was given instead of AOM initiation. Animals were sacrificed at week 12 to examine the development of aberrant crypt foci (ACF). A decreasing tendency was observed in the total number of ACF and sum of aberrant crypts in group 1 comparing with those of group 2. These results indicate that chitosan may have inhibiting effects to the development of preneoplastic lesions by azoxymethane and be a potential chemopreventive food component.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|